Description

A-(Fmoc-Amino)Tetrahydro-2H-Pyran-4-Acetic Acid is a sophisticated, high-purity building block designed for advanced organic synthesis. This compound is critical for the efficient and reliable construction of complex peptide and peptidomimetic structures, particularly in solid-phase peptide synthesis (SPPS). It is an essential raw material for pharmaceutical R&D and production, enabling the development of novel therapeutic agents and bioactive molecules.

Application

• As a key Fmoc-protected amino acid derivative in solid-phase peptide synthesis (SPPS).
• For the synthesis of peptidomimetics and constrained peptide analogs incorporating the tetrahydropyran scaffold.
• In the research and development of pharmaceutical intermediates for drug discovery programs.
• As a specialized building block for constructing macrocyclic compounds and other complex molecular architectures.
• For the preparation of linkers and conjugates in bioconjugation chemistry and prodrug development.
• In the synthesis of libraries for high-throughput screening in medicinal chemistry.

Basic Information

Product Name	A-(Fmoc-Amino)Tetrahydro-2H-Pyran-4-Acetic Acid
CAS No.	553643-51-9
Molecular Formula	C23H25NO6
Molecular Weight	411.45 g/mol
Synonyms	Fmoc-Amino-THP-Acetic Acid; 4-[(9H-Fluoren-9-ylmethoxy)carbonylamino]tetrahydro-2H-pyran-4-acetic Acid; (4-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}oxan-4-yl)acetic Acid; Fmoc-Ahpha-Amino-THP-AcOH; N-Fmoc-4-aminotetrahydropyran-4-acetic Acid; Fmoc-4-NH2-THP-4-CH2COOH; Fmoc-Amino(THP)AcOH
EINECS	Contact for details

Quality Control

Our production of A-(Fmoc-Amino)Tetrahydro-2H-Pyran-4-Acetic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are subjected to rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.