Description

5-(5-Isoxazyl)Thiophene-2-Sulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative used as a key synthetic intermediate in advanced organic chemistry. Its primary commercial value lies in its role as a versatile building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require a reliable source of high-purity intermediates for sulfonamide coupling reactions.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel sulfonamide-based drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides that incorporate the thiophene-sulfonyl moiety for enhanced activity.
• Material Science Research: Serves as a precursor for functionalized polymers and advanced organic electronic materials due to its conjugated thiophene core and reactive sulfonyl chloride group.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling and modifying biomolecules, facilitating studies in chemical biology and drug discovery.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for high-throughput screening.

Basic Information

Product Name	5-(5-Isoxazyl)Thiophene-2-Sulfonyl Chloride
CAS No.	551930-53-1
Molecular Formula	C7H4ClNO3S2
Molecular Weight	249.69 g/mol
Synonyms	5-(Isoxazol-5-yl)thiophene-2-sulfonyl chloride; 5-(1,2-Oxazol-5-yl)thiophene-2-sulfonyl chloride; Thiophene-2-sulfonyl chloride, 5-(5-isoxazolyl)-; 5-(5-Isoxazolyl)-2-thiophenesulfonyl chloride; 2-Thiophenesulfonyl chloride, 5-(5-isoxazolyl)-; 5-(1,2-Oxazol-5-yl)thiophene-2-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 5-(5-Isoxazyl)Thiophene-2-Sulfonyl Chloride adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure consistency and reliability for your synthetic workflows. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.