Description

4,6-Dimethyl-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced chemical synthesis. Its core value lies in the strategic combination of a pyrimidine scaffold with a carboxylic acid handle and a trifluoromethyl group, enabling precise molecular design and optimization. This compound is critically needed by R&D and production chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients, particularly where enhanced metabolic stability and lipophilicity are required.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of novel organic electronic materials, such as electron-transport layers or specialty polymers.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.
• Academic & Industrial R&D: Fundamental building block for exploratory chemistry in medicinal chemistry and chemical biology programs.

Basic Information

Product Name	4,6-Dimethyl-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid
CAS No.	544704-08-7
Molecular Formula	C8H7F3N2O2
Molecular Weight	220.15 g/mol
Synonyms	2-(Trifluoromethyl)-4,6-dimethylpyrimidine-5-carboxylic acid; 5-Pyrimidinecarboxylic acid, 4,6-dimethyl-2-(trifluoromethyl)-; 4,6-Dimethyl-2-trifluoromethylpyrimidine-5-carboxylic acid; DTFPCA; 544704-08-7
EINECS	Contact for details

Quality Control

Our production of 4,6-Dimethyl-2-(Trifluoromethyl)Pyrimidine-5-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor quality documentation to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.