Description

2,2,2-Trifluoro-n-(Pyrimidin-2-Yl)Acetamide is a high-purity fluorinated acetamide derivative featuring a pyrimidine ring, a structure of significant interest in advanced organic synthesis. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where the trifluoromethyl group can enhance metabolic stability and bioavailability. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for lead optimization and process chemistry.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Chemical Biology Probe Development: Serves as a precursor for labeling reagents or active site inhibitors used to study enzyme function and biological pathways.
• Material Science Research: Employed in the synthesis of specialty polymers or liquid crystals that require fluorinated aromatic components for specific electronic or surface properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds for client projects.

Basic Information

Product Name	2,2,2-Trifluoro-n-(Pyrimidin-2-Yl)Acetamide
CAS No.	544415-03-4
Molecular Formula	C6H4F3N3O
Molecular Weight	191.11 g/mol
Synonyms	2,2,2-Trifluoro-N-(pyrimidin-2-yl)acetamide; N-(Pyrimidin-2-yl)-2,2,2-trifluoroacetamide; 2,2,2-Trifluoroacetamide, N-2-pyrimidinyl-; Acetamide, 2,2,2-trifluoro-N-2-pyrimidinyl-; 2-Pyrimidinamine, N-(trifluoroacetyl)-; Trifluoroacetic acid pyrimidin-2-ylamide
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-n-(Pyrimidin-2-Yl)Acetamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.