Description

o-Methyl-D-Threonine is a specialized, non-proteinogenic amino acid derivative of significant interest in advanced organic synthesis and pharmaceutical research. This chiral building block is valued for its role in constructing complex peptide mimetics and bioactive molecules with high stereochemical fidelity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, chiral catalysts, and high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of peptide-based drugs, enzyme inhibitors, and other bioactive compounds.
• Peptide Synthesis: Used to incorporate modified threonine residues into custom peptides, altering their stability, bioavailability, or biological activity.
• Chiral Catalyst & Ligand Preparation: Serves as a precursor for synthesizing chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts.
• Biochemical Research: Employed in metabolic studies, enzyme-substrate interaction research, and as a standard in analytical method development.
• Fine Chemical Synthesis: A valuable building block for the custom synthesis of complex natural product analogs and specialty chemicals.

Basic Information

Product Name	o-Methyl-D-Threonine
CAS No.	537697-28-2
Molecular Formula	C5H11NO3
Molecular Weight	133.15 g/mol
Synonyms	D-3-Methylthreonine; (2R,3S)-2-Amino-3-methoxybutanoic acid; D-o-Methylthreonine; (2R,3S)-3-Methoxy-2-aminobutanoic acid; D-3-Methoxy-2-aminobutanoic acid; O-Methyl-D-threonine; D-Threonine O-methyl ether
EINECS	Contact for details

Quality Control

Our o-Methyl-D-Threonine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) providing purity, chiral excess, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.