Description

4-(Trifluoromethyl)Pyridine-3-Sulfonyl Chloride is a high-value, multi-functional chemical building block essential for advanced synthesis. Its core value lies in the reactive sulfonyl chloride group and the electron-withdrawing trifluoromethylpyridine scaffold, enabling the introduction of sulfonamide functionalities into complex molecules. This compound is critically needed by research and development chemists and process engineers in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, antimicrobials, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced activity and environmental profile.
• Material Science: Serves as a monomer or cross-linking agent for creating specialty polymers, coatings, and advanced functional materials.
• Chemical Biology & Proteomics: Utilized as a reactive handle for bioconjugation, activity-based protein profiling (ABPP), and probe development.
• Organic Synthesis: A versatile reagent for introducing the 4-(trifluoromethyl)pyridine-3-sulfonyl moiety into complex organic frameworks.
• Ligand & Catalyst Development: Employed in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-3-Sulfonyl Chloride
CAS No.	533932-27-3
Molecular Formula	C7H3ClF3NO2S
Molecular Weight	245.61 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)-3-pyridinesulfonyl chloride; 4-(Trifluoromethyl)pyridine-3-sulfonyl chloride; 4-Trifluoromethylpyridine-3-sulfonyl chloride; 3-Pyridinesulfonyl chloride, 4-(trifluoromethyl)-; 533932-27-3; 4-(Trifluoromethyl)pyridine-3-sulfonchlorid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-3-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.