Description

(Ala11,D-Leu15)-Orexin B (Human) CAS NO 532932-99-3 is a synthetic, modified peptide analog of the endogenous neuropeptide Orexin B (Hypocretin 2). This compound is of significant value for research into the orexin receptor system, which regulates critical physiological processes including sleep-wake cycles, arousal, and energy homeostasis. It is primarily needed by pharmaceutical R&D teams, academic neuroscientists, and biotechnology companies engaged in neuropharmacology, metabolic disorder research, and the development of novel therapeutics for sleep disorders and narcolepsy.

Application

• Neuroscience Research: Used as a selective tool compound for studying the structure-activity relationships (SAR) and signaling pathways of orexin receptors (OX1R and OX2R).
• Pharmacological Studies: Employed in in vitro and in vivo assays to investigate receptor binding affinity, agonist/antagonist activity, and downstream physiological effects.
• Drug Discovery & Development: Serves as a reference standard and a lead compound scaffold in the design of novel orexin receptor-targeting drugs for sleep disorders, addiction, and metabolic diseases.
• Academic & Clinical Research: Facilitates fundamental research into the role of the orexin system in appetite regulation, stress response, and cardiovascular function.
• Biochemical Reagent: Acts as a high-purity biochemical reagent in cell-based assays, calcium flux measurements, and other functional screening platforms.

Basic Information

Product Name	(Ala11,D-Leu15)-Orexin B (Human)
CAS No.	532932-99-3
Molecular Formula	C152H246N44O45S2
Molecular Weight	~3396.9 g/mol
Synonyms	[Ala11, D-Leu15]-Orexin B; [Ala11, D-Leu15]-Hypocretin 2; Modified Orexin B (Human); Orexin B Analog; Hypocretin-2 (11-28) amide, [Ala11,D-Leu15]-; (Ala11,D-Leu15)-hOrexin B; Orexin B (human) analog
EINECS	Contact for details

Quality Control

Our (Ala11,D-Leu15)-Orexin B (Human) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, MS, and amino acid analysis. We adhere to high standards suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccant and under an inert atmosphere to prevent oxidation. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, acetic acid, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.