Description

1,3-Benzodioxole-4-Methanamine, 2,2-Difluoro- CAS NO 531508-46-0 is a specialized fluorinated benzodioxole derivative, serving as a high-value building block in advanced organic synthesis. Its unique structure, featuring a difluoromethylenamino group fused to a 1,3-benzodioxole core, makes it a critical intermediate for introducing specific pharmacophores and modulating physicochemical properties. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used to construct advanced fungicides and herbicides, where the fluorinated benzodioxole moiety can improve activity and environmental profile.
• Material Science Research: Building block for developing specialty polymers and advanced organic electronic materials.
• Ligand and Catalyst Development: Serves as a sophisticated scaffold for creating novel ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable compound for academic and industrial research into the effects of strategic fluorine incorporation on molecular properties.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for proprietary synthesis projects requiring this specific fluorinated motif.

Basic Information

Product Name	1,3-Benzodioxole-4-Methanamine, 2,2-Difluoro-
CAS No.	531508-46-0
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	2,2-Difluoro-1,3-benzodioxole-4-methanamine; 4-(Aminomethyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxol-4-ylmethanamine; 2,2-Difluorobenzodioxole-4-methylamine; (2,2-Difluoro-1,3-benzodioxol-4-yl)methanamine; 2,2-Difluoro-4-(aminomethyl)-1,3-benzodioxole
EINECS	Contact for details

Quality Control

Our 1,3-Benzodioxole-4-Methanamine, 2,2-Difluoro- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.