Description

1,2-Difluoro-4-(Sulfinylamino)Benzene is a specialized fluorinated aromatic compound featuring a sulfinylamino functional group, making it a valuable synthetic intermediate. This compound matters for its role in constructing complex molecules, particularly in the development of pharmaceuticals and advanced materials where fluorine substitution is critical for modulating biological activity and physical properties. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for use in targeted synthesis and novel compound library generation.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated aromatic cores to enhance metabolic stability and membrane permeability.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and pesticides where the difluoro and sulfinylamino motifs can contribute to biological activity and selectivity.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of specialty polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probe Synthesis: Employed in medicinal chemistry for constructing molecular probes and tool compounds to study enzyme mechanisms and biological pathways.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to form complex biaryl structures.
• Sulfoxide Chemistry Studies: Used in methodological research exploring the reactivity of the sulfinylamino group in asymmetric synthesis and chiral auxiliary applications.

Basic Information

Product Name	1,2-Difluoro-4-(Sulfinylamino)Benzene
CAS No.	530102-74-0
Molecular Formula	C6H4F2NOS
Molecular Weight	175.16 g/mol
Synonyms	4-(Sulfinylamino)-1,2-difluorobenzene; 1,2-Difluoro-4-sulfinylaniline; Benzenamine, 1,2-difluoro-N-sulfinyl-; N-Sulfinyl-3,4-difluoroaniline; 3,4-Difluoro-N-sulfinylaniline; 1,2-Difluoro-4-aminosulfinylbenzene
EINECS	Contact for details

Quality Control

Every batch of 1,2-Difluoro-4-(Sulfinylamino)Benzene is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via techniques such as HPLC, GC, NMR, and IR spectroscopy is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.