Description

2-Chloro-5-Fluoro-4-Nitro-Phenol is a high-purity, multi-functional halogenated phenolic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring chloro, fluoro, and nitro substituents, makes it a versatile building block for creating complex molecules with tailored properties. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of active ingredients and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where the nitro-phenol scaffold provides essential bioactivity.
• Dye and Pigment Manufacturing: Serves as a starting material for synthesizing specialized azo dyes and colorants with enhanced light-fastness and chemical resistance.
• Material Science Research: Employed in the creation of novel polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for constructing complex biaryl structures.

Basic Information

Product Name	2-Chloro-5-Fluoro-4-Nitro-Phenol
CAS No.	524955-92-8
Molecular Formula	C6H3ClFNO3
Molecular Weight	191.54 g/mol
Synonyms	4-Nitro-2-chloro-5-fluorophenol; 2-Chloro-5-fluoro-4-nitrophenol; Phenol, 2-chloro-5-fluoro-4-nitro-; 5-Fluoro-2-chloro-4-nitrophenol; 2-Chloro-5-fluoronitrobenzene-4-ol; 4-Hydroxy-2-chloro-5-fluoronitrobenzene; 2-Chloro-5-fluoro-4-hydroxy-nitrobenzene
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoro-4-Nitro-Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during storage and handling.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.