Description

4-Chloro-5-Fluoroquinazoline Hydrochloride is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 524955-72-4. This compound is a critical building block in the synthesis of targeted small-molecule therapeutics, particularly kinase inhibitors. It is essential for research and development laboratories and production facilities in the global pharmaceutical and biotechnology sectors seeking reliable, high-quality raw materials for complex API synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel kinase inhibitor drugs for oncology and other therapeutic areas.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new quinazoline-based drug candidates.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in the manufacturing process of final active drug substances.
• Biochemical Research: Employed as a tool compound in biochemical assays to study enzyme inhibition and cellular signaling pathways.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production of clinical trial materials and commercial APIs.

Basic Information

Product Name	4-Chloro-5-Fluoroquinazoline Hydrochloride
CAS No.	524955-72-4
Molecular Formula	C8H4ClF2N2•HCl
Molecular Weight	233.04 g/mol (Free base: 197.58 g/mol)
Synonyms	4-Chloro-5-fluoroquinazoline HCl; 5-Fluoro-4-chloroquinazoline hydrochloride; Quinazoline, 4-chloro-5-fluoro-, hydrochloride (1:1); 4-Chloro-5-fluoroquinazoline monohydrochloride; CAS 524955-72-4
EINECS	Contact for details

Quality Control

Our 4-Chloro-5-Fluoroquinazoline Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and related substances. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with your research or cGMP production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.