Description

3-[2-(4-Methoxyphenyl)-4-Oxoquinazolin-3(4H)-Yl]-1,1-Dimethylthiourea is a high-purity, advanced pharmaceutical intermediate belonging to the quinazolinone class of heterocyclic compounds. This compound is of significant commercial interest for its role as a key building block in the synthesis of novel, biologically active molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of new therapeutic agents, particularly in oncology and other disease areas.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the multi-step synthesis of potential drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new chemical entities with improved efficacy and safety profiles.
• Biochemical Reagent: Employed in biochemical assays and as a tool compound for probing biological pathways and protein functions in academic and industrial R&D.
• Custom Synthesis: Available for contract manufacturing organizations (CMOs) and pharmaceutical companies requiring custom synthesis of complex molecules for clinical trial material (CTM) production.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-[2-(4-Methoxyphenyl)-4-Oxoquinazolin-3(4H)-Yl]-1,1-Dimethylthiourea
CAS No.	522660-13-5
Molecular Formula	C₁₉H₂₀N₄O₂S
Molecular Weight	368.45 g/mol
Synonyms	1,1-Dimethyl-3-[2-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-3-yl]thiourea; 3-[2-(4-Methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-3-yl]-1,1-dimethylthiourea; N,N-Dimethyl-N'-[2-(4-methoxyphenyl)-4-oxo-3,4-dihydroquinazolin-3-yl]thiourea; 522660-13-5; Quinazolinone thiourea derivative
EINECS	Contact for details

Quality Control

Our 3-[2-(4-Methoxyphenyl)-4-Oxoquinazolin-3(4H)-Yl]-1,1-Dimethylthiourea is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are provided and available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider inert atmosphere conditions to ensure stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.