Description

H-Thr(Ac)-Oh Hcl CAS NO 519156-32-2 is a protected derivative of the amino acid threonine, specifically N-acetyl-L-threonine hydrochloride. This compound is a critical building block in peptide synthesis, offering precise control over the threonine residue's side chain reactivity. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require high-purity, protected amino acids for the development of novel therapeutic peptides, APIs, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the sequential assembly of complex peptide chains in drug discovery and research.
• Solution-Phase Peptide Synthesis: Used in the synthesis of custom peptides, peptide hormones, and peptide-based active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Serves as a modified amino acid precursor for creating site-specifically labeled peptides for diagnostic and imaging applications.
• Pharmaceutical Intermediate: An important raw material in the multi-step synthesis of peptide drugs targeting metabolic disorders, cancers, and infectious diseases.
• Biochemical Research: Employed in studying protein structure-function relationships, enzyme substrates, and as a standard in analytical methods.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to identify new bioactive peptide leads.

Basic Information

Product Name	H-Thr(Ac)-Oh Hcl
CAS No.	519156-32-2
Molecular Formula	C6H12ClNO4
Molecular Weight	197.62 g/mol
Synonyms	N-Acetyl-L-threonine hydrochloride; (2S,3R)-2-Acetamido-3-hydroxybutanoic acid hydrochloride; Acetylthreonine HCl; H-Thr(Ac)-OH·HCl; L-Threonine, N-acetyl-, hydrochloride; N-Acetylthreonine hydrochloride; Fmoc-Thr(Ac)-OH precursor; Protected L-threonine derivative
EINECS	Contact for details

Quality Control

Our H-Thr(Ac)-Oh Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability, consistency, and compliance with your research or cGMP-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	[α]²⁰D: +15.0° to +20.0° (c=1 in H₂O)
Chiral Purity (HPLC)	≥99.0% L-isomer
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.