Description

4-(3,4-Dihydro-2H-1,5-Benzodioxepin-7-Yl)-6-(Trifluoromethyl)-2-Pyrimidinamine is a high-purity, advanced pharmaceutical intermediate characterized by its unique fused heterocyclic structure. This compound matters for its critical role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular scaffolds. Pharmaceutical R&D teams and fine chemical manufacturers need this precise building block to develop next-generation drug candidates with potentially improved efficacy and selectivity profiles.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the research and development of new drug molecules, especially in central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used in the discovery and synthesis of novel crop protection agents and pesticides, leveraging its pyrimidine core.
• Chemical Biology & Proteomics: Employed as a molecular probe or scaffold in studying enzyme inhibition and protein-ligand interactions.
• Material Science Research: Investigated for the development of specialty chemicals and advanced organic materials due to its fused ring system.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services.
• Academic Research: Utilized in university and institutional labs for methodological studies in heterocyclic and medicinal chemistry.

Basic Information

Product Name	4-(3,4-Dihydro-2H-1,5-Benzodioxepin-7-Yl)-6-(Trifluoromethyl)-2-Pyrimidinamine
CAS No.	519056-64-5
Molecular Formula	C15H12F3N3O2
Molecular Weight	323.27 g/mol
Synonyms	4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)-6-(trifluoromethyl)pyrimidin-2-amine; 6-(Trifluoromethyl)-4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-2-pyrimidinamine; 2-Pyrimidinamine, 4-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-6-(trifluoromethyl)-; CAS 519056-64-5; 4-(1,5-Benzodioxepin-7-yl)-6-(trifluoromethyl)-2-pyrimidinamine; 7-(2-Amino-6-(trifluoromethyl)pyrimidin-4-yl)-2,3-dihydro-1,5-benzodioxepine
EINECS	Contact for details

Quality Control

Our 4-(3,4-Dihydro-2H-1,5-Benzodioxepin-7-Yl)-6-(Trifluoromethyl)-2-Pyrimidinamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The product should be kept under an inert atmosphere if long-term storage is required to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.