Description

Fmoc-(R)-3-Amino-3-(3-Bromo-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a brominated aromatic side chain. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated synthesis of custom peptides containing bromo-phenylalanine analogs.
• Medicinal Chemistry & Drug Discovery: Used to incorporate a halogenated, hydrophobic aromatic group into peptide backbones for structure-activity relationship (SAR) studies and lead optimization.
• Peptidomimetic Development: Serves as a precursor for creating constrained or modified peptide-like molecules with enhanced metabolic stability and binding affinity.
• Chemical Biology Probes: Enables the synthesis of tagged or labeled peptides for studying protein-protein interactions and cellular pathways.
• Pharmaceutical Intermediate: A chiral synthon in the multi-step synthesis of potential active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Academic & Industrial Research: Essential for exploratory research in organic chemistry, biochemistry, and material science involving functionalized amino acids.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(3-Bromo-Phenyl)-Propionic Acid
CAS No.	517905-85-0
Molecular Formula	C24H20BrNO4
Molecular Weight	466.33 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(3-bromophenyl)propanoic Acid; (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-bromophenyl)propanoic Acid; Fmoc-3-(3-Bromo-phenyl)-D-homoalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-bromophenyl)-D-alanine; Fmoc-D-3-BrPhe(3)-OH; Fmoc-3-(3-Br-Ph)-D-Ala-OH; Nα-Fmoc-3-(3-bromophenyl)-D-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(3-Bromo-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.