Description

3-{[4-(4-Fluorophenyl)-6-(Trifluoromethyl)Pyrimidin-2-Yl]Thio}Propanoic Acid is a high-purity, advanced pharmaceutical intermediate featuring a unique pyrimidine-thioether scaffold. This compound is critical for research and development in medicinal chemistry, particularly for creating novel small-molecule therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted drug candidates.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new drug candidates.
• Agrochemical Development: Serves as a precursor in the research and synthesis of new-generation herbicides and fungicides with specific modes of action.
• Chemical Biology Probes: Employed in the development of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract research organizations (CROs) and CDMOs performing bespoke synthesis for client projects.

Basic Information

Product Name	3-{[4-(4-Fluorophenyl)-6-(Trifluoromethyl)Pyrimidin-2-Yl]Thio}Propanoic Acid
CAS No.	514180-29-1
Molecular Formula	C14H10F4N2O2S
Molecular Weight	346.30 g/mol
Synonyms	3-[[4-(4-Fluorophenyl)-6-(trifluoromethyl)-2-pyrimidinyl]thio]propanoic acid; 2-[(3-Carboxypropyl)thio]-4-(4-fluorophenyl)-6-(trifluoromethyl)pyrimidine; 514180-29-1; 3-({[4-(4-Fluorophenyl)-6-(trifluoromethyl)pyrimidin-2-yl]}sulfanyl)propanoic acid; 3-((4-(4-Fluorophenyl)-6-(trifluoromethyl)pyrimidin-2-yl)thio)propionic acid
EINECS	Contact for details

Quality Control

Our 3-{[4-(4-Fluorophenyl)-6-(Trifluoromethyl)Pyrimidin-2-Yl]Thio}Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, related substances, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.