Description

5-Pyrimidinecarboxylic Acid, 1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-4-[4-(Trifluoromethyl)Phenyl]-, Phenylmethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant commercial interest due to its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring targeted molecular design. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new drugs, agrochemicals, and other fine chemical products.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of proprietary drug candidates, especially those targeting central nervous system (CNS) disorders or metabolic diseases.
• Agrochemical Research: Serves as a scaffold for developing new herbicides, fungicides, or insecticides with specific activity profiles.
• Chemical Biology & Proteomics: Used as a molecular probe or a tagged ligand in biochemical assays to study enzyme inhibition and protein-ligand interactions.
• Material Science Research: Investigated as a monomer or additive for creating specialty polymers with unique thermal or optical properties.
• Contract Research & Development (CRO/CDMO): Supplied to organizations specializing in custom synthesis and process development for client-specific projects.

Basic Information

Product Name	5-Pyrimidinecarboxylic Acid, 1,2,3,4-Tetrahydro-6-Methyl-2-Oxo-4-[4-(Trifluoromethyl)Phenyl]-, Phenylmethyl Ester
CAS No.	512840-45-8
Molecular Formula	C20H17F3N2O3
Molecular Weight	390.36 g/mol
Synonyms	Benzyl 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]pyrimidine-5-carboxylate; 4-[4-(Trifluoromethyl)phenyl]-1,2,3,4-tetrahydro-6-methyl-2-oxopyrimidine-5-carboxylic acid phenylmethyl ester; 5-Pyrimidinecarboxylic acid, 1,2,3,4-tetrahydro-6-methyl-2-oxo-4-[4-(trifluoromethyl)phenyl]-, benzyl ester; Tetrahydro-6-methyl-2-oxo-4-(4-trifluoromethylphenyl)pyrimidine-5-carboxylic acid benzyl ester
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and purity. Every lot is subjected to comprehensive analytical testing, including HPLC for purity assay and identity confirmation via NMR and Mass Spectrometry. A detailed Certificate of Analysis (COA) documenting all test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.