Description

4-(3-Bromo-Phenyl)-1,6-Dimethyl-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester is a high-purity, advanced pharmaceutical intermediate of significant importance in modern synthetic chemistry. This compound serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic scaffolds. It is primarily needed by research institutions, custom synthesis firms, and pharmaceutical manufacturers engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those with dihydropyrimidinone (DHPM) core structures.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new therapeutic agents.
• Custom Synthesis: Serves as a starting material or intermediate for contract research organizations (CROs) and CDMOs producing specialized compounds.
• Chemical Library Development: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry reactions and methodologies.
• Process Chemistry: Acts as a model compound for developing and scaling up efficient synthetic routes for pharmaceutical manufacturing.

Basic Information

Product Name	4-(3-Bromo-Phenyl)-1,6-Dimethyl-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester
CAS No.	512840-37-8
Molecular Formula	C15H17BrN2O3
Molecular Weight	353.21 g/mol
Synonyms	Ethyl 4-(3-bromophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(3-Bromophenyl)-1,6-dimethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 1,2,3,4-Tetrahydro-4-(3-bromophenyl)-1,6-dimethyl-2-oxopyrimidine-5-carboxylic acid ethyl ester; 512840-37-8; 3-Bromo-DHPM ethyl ester; Biginelli derivative with 3-bromophenyl substituent
EINECS	Contact for details

Quality Control

Our 4-(3-Bromo-Phenyl)-1,6-Dimethyl-2-Oxo-1,2,3,4-Tetrahydro-Pyrimidine-5-Carboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.