Description

2-(1,5-Dimethyl-1H-Pyrazol-4-Yl)-3-Hydroxy-2,3-Dihydroquinazolin-4(1H)-One is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the research and development of novel therapeutic agents, particularly in oncology and central nervous system (CNS) drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing targeted small molecule inhibitors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel quinazolinone-based drug candidates targeting specific enzymes and receptors.
• Kinase Inhibitor Research: Core scaffold in the development of potent and selective kinase inhibitors for cancer therapy.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to optimize drug potency, selectivity, and pharmacokinetic properties.
• Biochemical Research: Serves as a reference standard or a tool compound in high-throughput screening (HTS) and in vitro biological assays.
• Custom Synthesis: Starting material for contract manufacturing organizations (CMOs) producing active pharmaceutical ingredients (APIs) under cGMP conditions.

Basic Information

Product Name	2-(1,5-Dimethyl-1H-Pyrazol-4-Yl)-3-Hydroxy-2,3-Dihydroquinazolin-4(1H)-One
CAS No.	512809-32-4
Molecular Formula	C₁₃H₁₄N₄O₂
Molecular Weight	258.28 g/mol
Synonyms	3-Hydroxy-2-(1,5-dimethyl-1H-pyrazol-4-yl)-1,2-dihydro-4(3H)-quinazolinone; 2-(1,5-Dimethyl-1H-pyrazol-4-yl)-3-hydroxy-1,2-dihydroquinazolin-4-one; 4(1H)-Quinazolinone, 2,3-dihydro-3-hydroxy-2-(1,5-dimethyl-1H-pyrazol-4-yl)-; 512809-32-4
EINECS	Contact for details

Quality Control

Our 2-(1,5-Dimethyl-1H-Pyrazol-4-Yl)-3-Hydroxy-2,3-Dihydroquinazolin-4(1H)-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with each shipment, ensuring traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.