Description

4'-α-C-Allyl-2',3'-Bis(o-T-Butyldimethylsilyl)Uridine is a sophisticated, silyl-protected nucleoside derivative, a critical building block in advanced organic synthesis. This compound matters for its role in constructing complex oligonucleotide analogs with precise control over stereochemistry and functional group reactivity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, including antisense oligonucleotides, siRNA, and other nucleic acid-based modalities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of modified nucleosides and nucleotides for therapeutic applications.
• Antisense Oligonucleotide (ASO) Research: Used in the solid-phase or solution-phase synthesis of oligonucleotides designed for gene silencing.
• siRNA and miRNA Synthesis: Essential building block for creating small interfering RNA (siRNA) and microRNA (miRNA) analogs with enhanced stability and delivery properties.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop novel antiviral and anticancer agents.
• Chemical Biology Probes: Utilized to create labeled or modified nucleotides for studying nucleic acid interactions and enzyme mechanisms.
• Process Development: Serves as a high-value intermediate in scaling up the production of active pharmaceutical ingredients (APIs) for clinical trials.

Basic Information

Product Name	4'-α-C-Allyl-2',3'-Bis(o-T-Butyldimethylsilyl)Uridine
CAS No.	512184-18-8
Molecular Formula	C24H46N2O6Si2
Molecular Weight	514.81 g/mol
Synonyms	4'-α-C-Allyl-2',3'-bis-O-(tert-butyldimethylsilyl)uridine; 2',3'-Bis-O-(tert-butyldimethylsilyl)-4'-C-allyluridine; 4'-C-Allyl-2',3'-di-O-(tert-butyldimethylsilyl)uridine; Uridine, 4'-C-allyl-2',3'-bis-O-[(1,1-dimethylethyl)dimethylsilyl]-; 4'-Allyl-2',3'-bis-TBDMS-uridine; TBDMS-protected 4'-C-allyluridine; 4'-C-Allyl-2',3'-di-O-TBDMS-uridine
EINECS	Contact for details

Quality Control

Our production of 4'-α-C-Allyl-2',3'-Bis(o-T-Butyldimethylsilyl)Uridine adheres to stringent quality protocols suitable for research and pharmaceutical development. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and NMR for structural confirmation. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to ensure traceability and batch-to-batch consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled, dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.