Description

Fmoc-(R)-3-Amino-3-(1-Naphthyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a bulky 1-naphthyl side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, where it introduces structural rigidity and aromatic character. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and CROs engaged in developing novel therapeutic peptides, protein engineering, and chemical biology research.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral monomer for the automated synthesis of custom peptides with specific structural motifs.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates to enhance binding affinity, metabolic stability, and bioavailability.
• Peptidomimetic Design: Serves as a scaffold for creating non-peptide compounds that mimic the function of natural peptides.
• Chemical Biology Probes: Used in the synthesis of labeled peptides for studying protein-protein interactions and enzyme mechanisms.
• Material Science: Potential use in the synthesis of functionalized polymers and advanced biomaterials with specific chiral properties.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(1-Naphthyl)-Propionic Acid
CAS No.	511272-47-2
Molecular Formula	C28H23NO4
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(1-naphthyl)propanoic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic Acid; Fmoc-R-1-Nal-OH; Fmoc-(R)-1-Naphthylalanine; N-α-Fmoc-(R)-1-naphthylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-1-naphthyl-(R)-alanine; Fmoc-(R)-1-Nal; Fmoc-D-1-Nal-OH
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(1-Naphthyl)-Propionic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity, essential for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards for fine chemicals and can provide material suitable for research and development under cGMP guidelines upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.