Description

Fmoc-(R)-3-Amino-3-(3-Thienyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a thiophene side chain, making it a critical chiral building block for advanced peptide synthesis. This compound is essential for researchers and manufacturers developing novel peptide-based pharmaceuticals and bioactive compounds, where precise stereochemistry and side-chain functionality are paramount. It is primarily utilized in solid-phase peptide synthesis (SPPS) for the production of complex peptides with enhanced stability, bioavailability, and targeted therapeutic effects.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key chiral amino acid building block for the automated synthesis of complex therapeutic peptides.
• Pharmaceutical Research & Development: For the discovery and development of novel peptide drugs, including antimicrobial peptides (AMPs), hormone analogs, and enzyme inhibitors.
• Peptidomimetics Design: Incorporation into peptide backbones to create mimetics with improved metabolic stability and receptor binding affinity, leveraging the unique properties of the thienyl group.
• Chemical Biology Probes: Used in the synthesis of labeled or modified peptides for studying protein-protein interactions, enzyme mechanisms, and cellular pathways.
• Combinatorial Chemistry Libraries: Serves as a valuable component in generating diverse libraries of peptide-like compounds for high-throughput screening against biological targets.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(3-Thienyl)-Propionic Acid
CAS No.	511272-46-1
Molecular Formula	C22H19NO4S
Molecular Weight	393.45 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(3-thienyl)propanoic Acid; (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(thiophen-3-yl)propanoic Acid; Fmoc-β3-hThi(R)-OH; N-α-Fmoc-3-(3-thienyl)-(R)-β-homoalanine; Fmoc-(R)-3-(3-Thienyl)-β-homoalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-thienyl)-D-β-homoalanine; Fmoc-D-β3-Thi
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for pharmaceutical intermediates and research chemicals. Every batch is characterized using advanced analytical techniques to guarantee identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, providing detailed results for key parameters such as assay (HPLC), chiral purity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.