Description

Fmoc-(R)-3-Amino-3-(3-Methoxy-Phenyl)-Propionic Acid is a non-natural, chiral amino acid derivative protected with a fluorenylmethyloxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise construction of complex peptides and peptidomimetics. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy, used in automated synthesizers to incorporate a specific chiral, non-natural residue into peptide chains.
• Pharmaceutical Research: Serves as a crucial intermediate in the discovery and development of novel peptide-based drugs, including hormone analogs, enzyme inhibitors, and receptor agonists/antagonists.
• Peptidomimetic Design: Used to create modified peptides with enhanced stability, bioavailability, or biological activity by introducing a methoxy-phenyl side chain.
• Bioconjugation and Probe Development: Acts as a starting material for synthesizing labeled peptides or peptide conjugates used in diagnostic assays and imaging.
• Combinatorial Chemistry Libraries: Employed to generate diverse libraries of peptide-like compounds for high-throughput screening against biological targets.

Basic Information

Product Name	Fmoc-(R)-3-Amino-3-(3-Methoxy-Phenyl)-Propionic Acid
CAS No.	511272-32-5
Molecular Formula	C25H23NO5
Molecular Weight	417.45 g/mol
Synonyms	Fmoc-(R)-3-Amino-3-(3-methoxyphenyl)propanoic Acid; (R)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-methoxyphenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-D-homophenylalanine; Fmoc-D-3-Methoxy-homoPhe-OH; Fmoc-D-Met-hPhe-OH; Nα-Fmoc-3-methoxy-D-homophenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-3-(3-Methoxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, correct stereochemistry, and consistency. Certificates of Analysis (COA) detailing purity (typically by HPLC), chiral purity, and other critical parameters are available for every shipment to support your cGMP or research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be kept under inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.