Description

Fmoc-(S)-3-Amino-3-(1-Naphthyl)-Propionic Acid is a high-purity, non-natural amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound is essential for introducing the unique steric and aromatic properties of the 1-naphthyl group into peptide chains, enabling the creation of specialized peptides with enhanced binding affinity or altered pharmacokinetic profiles. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs developing novel therapeutic peptides, peptidomimetics, and chemical biology probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides containing a bulky, hydrophobic side chain.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates targeting protein-protein interactions, GPCRs, or enzyme active sites where aromatic stacking is crucial.
• Peptidomimetic Design: Serves as a scaffold for developing metabolically stable analogs and constrained peptides for therapeutic applications.
• Chemical Biology & Proteomics: Used to create tagged peptides, activity-based probes, or affinity ligands to study biological processes.
• Material Science: Potential use in the synthesis of peptide-based polymers or nanomaterials where aromatic moieties influence self-assembly and properties.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(1-Naphthyl)-Propionic Acid
CAS No.	507472-10-8
Molecular Formula	C₂₈H₂₃NO₄
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-3-(1-Naphthyl)-D-alanine; Fmoc-β-(1-Naphthyl)-D-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(1-naphthyl)-D-alanine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(naphthalen-1-yl)propanoic acid; Fmoc-D-1-Nal-OH; Fmoc-1-Naphthylalanine; Fmoc-(R)-3-Amino-3-(1-naphthyl)propanoic acid; N-α-Fmoc-1-naphthylalanine
EINECS	Contact for details

Quality Control

Every batch of Fmoc-(S)-3-Amino-3-(1-Naphthyl)-Propionic Acid is manufactured and tested under strict quality management systems. We guarantee high chemical purity and chiral integrity, which are critical for reproducible results in peptide synthesis. Comprehensive analytical testing, including HPLC, NMR, and optical rotation, is performed to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label. This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.