Description

{[4-Phenyl-6-(Trifluoromethyl)Pyrimidin-2-Yl]Thio}Acetic Acid is a high-value, multifunctional heterocyclic building block characterized by its pyrimidine core, phenyl ring, and trifluoromethyl group. This compound matters for its role as a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its unique structure imparts desirable properties like metabolic stability and lipophilicity. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing novel compounds and fine-tuning molecular properties.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the bioactivity of the pyrimidine-thioacetic acid moiety.
• Material Science Research: Acts as a building block for creating functionalized polymers or organic electronic materials due to its aromatic and electron-withdrawing groups.
• Chemical Biology Probes: Employed in the design of molecular probes and enzyme inhibitors for biochemical and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthetic routes.
• Academic & Industrial R&D: Utilized in exploratory chemistry for discovering new reactions and creating compound libraries for screening.

Basic Information

Product Name	{[4-Phenyl-6-(Trifluoromethyl)Pyrimidin-2-Yl]Thio}Acetic Acid
CAS No.	506418-83-3
Molecular Formula	C₁₃H₉F₃N₂O₂S
Molecular Weight	314.28 g/mol
Synonyms	2-({[4-Phenyl-6-(trifluoromethyl)pyrimidin-2-yl]thio})acetic acid; [4-Phenyl-6-(trifluoromethyl)-2-pyrimidinyl]thioacetic Acid; 2-[[4-Phenyl-6-(trifluoromethyl)pyrimidin-2-yl]sulfanyl]acetic acid; (4-Phenyl-6-trifluoromethyl-pyrimidin-2-ylsulfanyl)-acetic acid; 506418-83-3; 4-Phenyl-6-(trifluoromethyl)pyrimidine-2-thioacetic Acid
EINECS	Contact for details

Quality Control

Our {[4-Phenyl-6-(Trifluoromethyl)Pyrimidin-2-Yl]Thio}Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be moisture-sensitive; keep the container tightly sealed in a dry environment. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.