Description

tert-Butyl 2-Formyl-4-(Trifluoromethoxy)Phenylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethoxy and formyl functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutics targeting the central nervous system and metabolic diseases. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in medicinal chemistry and process development, where its consistent quality and reliable supply are paramount for successful drug discovery and scale-up.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those requiring the trifluoromethoxy moiety for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents for CNS disorders and other disease areas.
• Process Chemistry Development: Serves as a critical starting material or intermediate in the development and scaling of robust, cost-effective synthetic routes for API manufacturing.
• Agrochemical Synthesis: Potential intermediate in the research and development of advanced crop protection agents, leveraging the biological activity of the trifluoromethoxy group.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized compounds under cGMP conditions.

Basic Information

Product Name	tert-Butyl 2-Formyl-4-(Trifluoromethoxy)Phenylcarbamate
CAS No.	505084-60-6
Molecular Formula	C13H14F3NO4
Molecular Weight	305.25 g/mol
Synonyms	Carbamic acid, N-[2-formyl-4-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester; 2-Formyl-4-(trifluoromethoxy)phenyl tert-butylcarbamate; tert-Butyl N-[2-formyl-4-(trifluoromethoxy)phenyl]carbamate; BOC-2-formyl-4-(trifluoromethoxy)aniline; 2-Formyl-4-(trifluoromethoxy)aniline N-BOC derivative
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Formyl-4-(Trifluoromethoxy)Phenylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and conformity to stringent specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. We support development and commercial projects requiring material produced under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.