Description

2-Chloro-3-Fluorobenzenesulfonyl Chloride is a versatile and highly reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to introduce the 2-chloro-3-fluorobenzenesulfonyl moiety, a key functional group for modulating the biological activity and physicochemical properties of target molecules. This intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for sulfonamide-based drugs targeting various therapeutic areas.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the sulfonyl group contributes to efficacy and selectivity.
• Material Science: Acts as a monomer or cross-linking agent in the production of specialty polymers and functional materials.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring new reaction pathways and creating compound libraries for screening.
• Dye and Pigment Manufacturing: Intermediate in the synthesis of complex organic dyes and pigments.

Basic Information

Product Name	2-Chloro-3-Fluorobenzenesulfonyl Chloride
CAS No.	504424-79-7
Molecular Formula	C6H3Cl2FO2S
Molecular Weight	229.06 g/mol
Synonyms	2-Chloro-3-fluorobenzene-1-sulfonyl chloride; 1-Chloro-2-fluoro-6-(chlorosulfonyl)benzene; 3-Fluoro-2-chlorobenzenesulfonyl chloride; Benzenesulfonyl chloride, 2-chloro-3-fluoro-; 2-Chloro-3-fluorophenylsulfonyl chloride
EINECS	Contact for details

Quality Control

Our 2-Chloro-3-Fluorobenzenesulfonyl Chloride is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can tailor quality protocols to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation from moisture and ensure product integrity. Keep away from heat, open flames, and incompatible materials such as bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.