Description

6-Amino-2-([(2,3-Difluorophenyl)Methyl]Sulfanyl)-3,4-Dihydropyrimidin-4-One is a high-value, functionalized dihydropyrimidinone derivative that serves as a critical synthetic intermediate in advanced pharmaceutical research and development. Its molecular architecture, featuring a 2,3-difluorobenzylthio substituent and an amino group, makes it a versatile building block for constructing complex heterocyclic systems with potential biological activity. This compound is primarily sought after by medicinal chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Agrochemical Development: Building block for creating new fungicides or herbicides that leverage its heterocyclic and fluorinated motifs.
• Chemical Biology Probes: Utilized in the development of tool compounds and probes for studying enzymatic pathways and biological targets.
• Process Chemistry & Scale-Up: Serves as a defined intermediate for optimizing synthetic routes and scaling up production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	6-Amino-2-([(2,3-Difluorophenyl)Methyl]Sulfanyl)-3,4-Dihydropyrimidin-4-One
CAS No.	503271-69-0
Molecular Formula	C11H9F2N3OS
Molecular Weight	269.27 g/mol
Synonyms	6-Amino-2-[(2,3-difluorobenzyl)thio]-3,4-dihydropyrimidin-4(3H)-one; 2-((2,3-Difluorobenzyl)thio)-6-amino-3,4-dihydropyrimidin-4-one; 4(3H)-Pyrimidinone, 6-amino-2-[(2,3-difluorophenyl)methyl]thio]-3,4-dihydro-; CAS 503271-69-0
EINECS	Contact for details

Quality Control

Our 6-Amino-2-([(2,3-Difluorophenyl)Methyl]Sulfanyl)-3,4-Dihydropyrimidin-4-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening containers to maintain purity and stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.