Description

Ethyl 2-(2-Butyl-4-Methyl-6-Oxo-1-((2'-(1-Trityl-1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1,6-Dihydropyrimidin-5-Yl)Acetate is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of critical importance in the synthesis of active pharmaceutical ingredients (APIs), particularly in the sartan class of cardiovascular drugs. It is primarily required by pharmaceutical R&D laboratories and contract manufacturing organizations (CMOs) for the development and production of next-generation therapeutics.

Application

• Key Intermediate in Sartan API Synthesis: Serves as a crucial building block in the manufacturing of angiotensin II receptor blockers (ARBs), a major class of antihypertensive medications.
• Pharmaceutical Research & Development: Used in medicinal chemistry for the discovery and optimization of new drug candidates targeting cardiovascular and metabolic diseases.
• Process Chemistry & Scale-Up: Employed in the development of robust, scalable synthetic routes for commercial API production under cGMP conditions.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory submissions in pharmaceutical manufacturing.
• Custom Synthesis: Utilized as a starting material for the preparation of novel, structurally related analogs for biological screening and patenting.

Basic Information

Product Name	Ethyl 2-(2-Butyl-4-Methyl-6-Oxo-1-((2'-(1-Trityl-1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1,6-Dihydropyrimidin-5-Yl)Acetate
CAS No.	503155-66-6
Molecular Formula	C50H46N6O3
Molecular Weight	778.95 g/mol
Synonyms	Ethyl 2-(2-Butyl-4-methyl-6-oxo-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,6-dihydropyrimidin-5-yl)acetate; 503155-66-6; Valsartan Trityl Tetrazole Intermediate; Valsartan Advanced Intermediate; 5-(2-Ethoxy-2-oxoethyl)-2-butyl-4-methyl-6-oxo-1-{[2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1,6-dihydropyrimidine; Valsartan Key Intermediate; Trityl Valsartan Intermediate; N-Trityl Valsartan Ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(2-Butyl-4-Methyl-6-Oxo-1-((2'-(1-Trityl-1H-Tetrazol-5-Yl)-[1,1'-Biphenyl]-4-Yl)Methyl)-1,6-Dihydropyrimidin-5-Yl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to ICH Q7 guidelines for pharmaceutical intermediates, ensuring suitability for use in regulated drug substance synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants and maintaining an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.