Description

Butanoic Acid, 2-[[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Methyl]-3-Methyl-, (2R)- is a specialized, optically active amino acid derivative protected with the 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound matters as a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise and efficient construction of complex peptides and proteins. Pharmaceutical researchers and fine chemical manufacturers need this high-purity intermediate for developing therapeutic peptides, diagnostic agents, and advanced biomaterials.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it serves as a key monomer for the sequential assembly of peptide chains on resin supports.
• Pharmaceutical Intermediates: Used in the research and development of novel peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation: Employed to introduce specific functional groups or side chains into larger biomolecules for labeling or modification.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Industrial Research: Essential for studies in biochemistry, molecular biology, and medicinal chemistry focused on protein structure and function.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Butanoic Acid, 2-[[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]Methyl]-3-Methyl-, (2R)-
CAS No.	501331-02-8
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-D-2-Methylleucine; Fmoc-D-2-MeLeu-OH; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methylbutanoic acid; Fmoc-D-2-methylleucine; Fmoc-D-MeLeu-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-D-valine; Fmoc-2-methyl-D-leucine; Nα-Fmoc-2-methyl-D-leucine
EINECS	Contact for details

Quality Control

Our Fmoc-D-2-Methylleucine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive applications like peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant industry standards and can support projects requiring documentation for research or cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.