Description

(3S)-3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Pyridin-2-Yl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a pyridyl side chain and an Fmoc-protected amine group, making it a critical building block for advanced peptide synthesis and medicinal chemistry research. Its primary value lies in enabling the precise construction of complex peptide sequences with enhanced stability and specific binding properties. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, peptidomimetics, and as a key intermediate in solid-phase peptide synthesis (SPPS).

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a crucial Fmoc-protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical R&D: Used in the discovery and development of novel peptide-based drugs, including enzyme inhibitors and receptor agonists/antagonists.
• Peptidomimetic Design: The pyridin-2-yl moiety provides a heterocyclic scaffold for designing molecules that mimic peptide structure and function with improved metabolic stability.
• Bioconjugation & Probe Development: Acts as a specialty linker or modified amino acid for creating fluorescent probes, affinity tags, or drug conjugates.
• Chemical Biology Studies: Employed to incorporate specific structural motifs into peptides to study protein-protein interactions and biological pathways.
• Process Development: Used as a reference standard or intermediate in scaling up the production of therapeutic peptide APIs.

Basic Information

Product Name	(3S)-3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Pyridin-2-Yl)Propanoic Acid
CAS No.	501015-39-0
Molecular Formula	C24H20N2O4
Molecular Weight	400.43 g/mol
Synonyms	Fmoc-3-(2-Pyridyl)-L-alanine; Fmoc-(3-pyridin-2-yl)-L-alanine; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(pyridin-2-yl)propanoic acid; N-α-Fmoc-3-(2-pyridyl)-L-alanine; Fmoc-L-3-(2-Pyridyl)alanine; Fmoc-3-(2-Pyridinyl)-L-alanine; N-Fmoc-3-(2-pyridyl)-L-alanine; Fmoc-3-Pyrid-2-yl-L-alanine
EINECS	Contact for details

Quality Control

Our (3S)-3-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(Pyridin-2-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.