Description

Fmoc-(S)-3-Amino-3-(3-Hydroxy-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a free carboxylic acid, designed for solid-phase peptide synthesis (SPPS). This compound is critical for the efficient and controlled assembly of complex peptides, enabling the incorporation of a phenolic hydroxyl side chain for specific bioactivity or conjugation. It is an essential building block for pharmaceutical R&D, particularly in developing therapeutic peptides, diagnostic probes, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid building block for the automated synthesis of custom peptides.
• Pharmaceutical Research: Used in the development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation & Probe Development: The phenolic hydroxyl group serves as a handle for site-specific labeling with fluorescent dyes, biotin, or other functional moieties.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Academic & Biochemical Research: Utilized to study protein-protein interactions, receptor binding, and signal transduction pathways using synthetic peptide fragments.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(3-Hydroxy-Phenyl)-Propionic Acid
CAS No.	501015-32-3
Molecular Formula	C24H21NO5
Molecular Weight	403.43 g/mol
Synonyms	Fmoc-3-Amino-3-(3-hydroxyphenyl)propanoic acid; Fmoc-(S)-3-Amino-3-(3-hydroxyphenyl)propionic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(3-hydroxyphenyl)propanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-hydroxyphenyl)propanoic acid; Fmoc-3-(3-Hydroxyphenyl)-β-alanine; Fmoc-3-(3-Hydroxyphenyl)-β-homoalanine; Fmoc-Hph(3-OH)-OH
EINECS	Contact for details

Quality Control

Every batch of Fmoc-(S)-3-Amino-3-(3-Hydroxy-Phenyl)-Propionic Acid is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for peptide synthesis. Our quality commitment includes providing a detailed Certificate of Analysis (COA) with each shipment, verifying identity, purity (typically ≥98% by HPLC), and chiral integrity. Specifications are aligned with the needs of cGMP and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and light-sensitive; prolonged exposure to air, moisture, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.