Description

Fmoc-(S)-3-Amino-3-(2-Methoxy-Phenyl)-Propionic Acid is a high-purity, non-natural amino acid derivative featuring a fluorenylmethyloxycarbonyl (Fmoc) protecting group on the amine and a carboxylic acid functionality. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the precise incorporation of a methoxy-substituted phenylalanine analog. It is essential for researchers and manufacturers in pharmaceutical R&D, biotechnology, and academic laboratories developing novel therapeutic peptides, protease inhibitors, and bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides and peptide libraries.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based drugs, including GPCR-targeted therapies and enzyme inhibitors.
• Peptidomimetic Design: Incorporates a constrained, aromatic side chain to modulate peptide backbone conformation and enhance metabolic stability.
• Bioconjugation & Probe Development: Serves as a building block for creating labeled peptides or affinity probes for biochemical assays.
• Academic & Contract Research: Employed in university and CRO settings for fundamental research in medicinal chemistry and chemical biology.

Basic Information

Product Name	Fmoc-(S)-3-Amino-3-(2-Methoxy-Phenyl)-Propionic Acid
CAS No.	501015-28-7
Molecular Formula	C26H25NO5
Molecular Weight	431.48 g/mol
Synonyms	Fmoc-3-Amino-3-(2-methoxyphenyl)propanoic acid; Fmoc-(S)-Amino(2-methoxyphenyl)acetic acid, β-homo; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(2-methoxyphenyl)propanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(2-methoxyphenyl)propanoic acid; Fmoc-2-Methoxy-D-homoPhe-OH; Fmoc-β-homo-2-methoxy-L-phenylalanine; Fmoc-(S)-3-(2-Methoxyphenyl)-β-alanine; Nα-Fmoc-3-amino-3-(2-methoxyphenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-3-(2-Methoxy-Phenyl)-Propionic Acid is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, and is supplied with a comprehensive Certificate of Analysis (COA). We support cGMP and ISO compliant production for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and purity. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.