Description

n-[[2-Cyano-4-(2,2-Dimethylpropylamino)Pyrimidin-5-Yl]Methyl]-4-(4-Methylpiperazin-1-Yl)Benzamide is a high-purity, advanced pharmaceutical intermediate with a complex heterocyclic structure. This compound matters for its critical role as a key building block in the synthesis of targeted therapeutic agents, particularly in oncology and other specialized drug development pipelines. Pharmaceutical R&D teams, fine chemical manufacturers, and contract research organizations (CROs) require this material for its precise chemical functionality to enable the production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Primary use as a sophisticated building block in the multi-step synthesis of novel drug candidates, especially kinase inhibitors.
• Oncology Research: Serves as a core scaffold in the development of targeted cancer therapies due to its pyrimidine and benzamide pharmacophores.
• Preclinical & Clinical Development: Used in the preparation of compounds for pharmacological screening, toxicology studies, and early-phase clinical trial material.
• Process Chemistry & Scale-Up: Essential for process research and development (PR&D) and the optimization of synthetic routes for commercial API manufacturing.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying specific biological pathways and target validation.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific molecules.

Basic Information

Item	Details
Product Name	n-[[2-Cyano-4-(2,2-Dimethylpropylamino)Pyrimidin-5-Yl]Methyl]-4-(4-Methylpiperazin-1-Yl)Benzamide
CAS No.	501000-36-8
Molecular Formula	C24H32N8O
Molecular Weight	448.57 g/mol
Synonyms	4-(4-Methyl-1-piperazinyl)-N-[[2-cyano-4-[(2,2-dimethylpropyl)amino]-5-pyrimidinyl]methyl]benzamide; Benzamide, N-[[2-cyano-4-[(2,2-dimethylpropyl)amino]-5-pyrimidinyl]methyl]-4-(4-methyl-1-piperazinyl)-; CAS 501000-36-8; 4-(4-Methylpiperazin-1-yl)-N-({2-cyano-4-[(2,2-dimethylpropyl)amino]pyrimidin-5-yl}methyl)benzamide; 501000-36-8; UNII-6H8V3I4Q6F; 6H8V3I4Q6F
EINECS	Contact for details

Quality Control

Our n-[[2-Cyano-4-(2,2-Dimethylpropylamino)Pyrimidin-5-Yl]Methyl]-4-(4-Methylpiperazin-1-Yl)Benzamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.