Description

Methyl (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Methylsulfanylbutanoate CAS NO 500872-34-4 is a high-purity, protected amino acid derivative primarily used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters for its role in enabling the precise and efficient construction of complex peptides and peptidomimetics, where it introduces a methionine-like side chain with a protected thioether functionality. Pharmaceutical R&D laboratories and fine chemical manufacturers need this reagent for developing therapeutic peptides, research biochemicals, and novel drug candidates.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid derivative for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Linker Chemistry: Serves as a precursor for creating thioether linkages or for introducing methionine analogs into biomolecules.
• Chemical Biology & Proteomics: Employed in the synthesis of peptide probes, substrates, and inhibitors for enzyme studies and biochemical assays.
• Fine Chemical Synthesis: Acts as a chiral synthon for the preparation of more complex, non-natural amino acids and specialized organic compounds.

Basic Information

Product Name	Methyl (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Methylsulfanylbutanoate
CAS No.	500872-34-4
Molecular Formula	C21H23NO4S
Molecular Weight	385.48 g/mol
Synonyms	Fmoc-Met-OMe; Fmoc-Methionine Methyl Ester; Methyl N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-methioninate; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-(methylthio)butanoic acid methyl ester; L-Methionine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, methyl ester; Fmoc-L-methionine methyl ester; N-α-Fmoc-L-methionine methyl ester; Methyl (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(methylthio)butanoate
EINECS	Contact for details

Quality Control

Our Methyl (2S)-2-(9H-Fluoren-9-Ylmethoxycarbonylamino)-4-Methylsulfanylbutanoate is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and synthesis applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and moisture analysis. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.