Description

2-Bromo-3,5-Difluorobenzenamine is a versatile halogenated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine and fluorine substituents, makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring halogenated aromatic cores for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and bromo groups can enhance binding affinity and environmental persistence.
• Material Science Research: Employed in the creation of specialty polymers, liquid crystals, and organic electronic materials due to its ability to modify electronic properties.
• Cross-Coupling Reactions: Serves as a substrate in Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling reactions to form complex biaryl and amine structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry teams exploring new synthetic pathways and compound libraries.

Basic Information

Product Name	2-Bromo-3,5-Difluorobenzenamine
CAS No.	500357-40-4
Molecular Formula	C6H4BrF2N
Molecular Weight	208.00 g/mol
Synonyms	2-Bromo-3,5-difluoroaniline; 3,5-Difluoro-2-bromoaniline; Benzenamine, 2-bromo-3,5-difluoro-; 2-Bromo-3,5-difluorophenylamine; 2-Bromo-3,5-difluoro-benzenamine; 2-Bromo-3,5-difluoroaniline (primary name); 500357-40-4 (CAS Index Name)
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3,5-Difluorobenzenamine is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical syntheses. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development, ensuring traceability and documentation excellence.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.