Description

(5E)-5-{[2,5-Dimethyl-1-(Propan-2-Yl)-1H-Pyrrol-3-Yl]Methylidene}-1-(4-Fluorophenyl)-2-Thioxodihydropyrimidine-4,6(1H,5H)-Dione is a high-purity, non-nucleoside heterocyclic compound featuring a unique pyrrole-pyrimidine-dione core structure. This compound is of significant interest as a key synthetic intermediate and a versatile scaffold for advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and advanced material research organizations engaged in the discovery of novel bioactive molecules and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of potential drug candidates, particularly in oncology, antiviral, and CNS therapeutic areas.
• Agrochemical Research: Used as a precursor in the development of new pesticides, herbicides, and fungicides due to its complex heterocyclic structure.
• Chemical Biology Probe: Acts as a molecular scaffold for designing probes to study enzyme inhibition and protein-ligand interactions.
• Material Science Research: Investigated for its potential in creating novel organic electronic materials or metal-organic frameworks (MOFs).
• Academic & Contract Research: Utilized in universities and CROs for methodological studies in organic synthesis and heterocyclic chemistry.
• Custom Synthesis Starting Point: Provides a sophisticated core for contract manufacturing organizations (CMOs) to develop proprietary compounds for clients.

Basic Information

Product Name	(5E)-5-{[2,5-Dimethyl-1-(Propan-2-Yl)-1H-Pyrrol-3-Yl]Methylidene}-1-(4-Fluorophenyl)-2-Thioxodihydropyrimidine-4,6(1H,5H)-Dione
CAS No.	500135-54-6
Molecular Formula	C20H20FN3O2S
Molecular Weight	385.46 g/mol
Synonyms	5-[(2,5-Dimethyl-1-isopropyl-1H-pyrrol-3-yl)methylene]-1-(4-fluorophenyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 1-(4-Fluorophenyl)-5-[(2,5-dimethyl-1-propan-2-yl-1H-pyrrol-3-yl)methylidene]-2-sulfanylidenepyrimidine-4,6-dione; (5E)-5-[(2,5-Dimethyl-1-isopropyl-1H-pyrrol-3-yl)methylene]-1-(4-fluorophenyl)-2-thioxo-1,3-diazinane-4,6-dione; 500135-54-6; 5-[(2,5-Dimethyl-1-isopropylpyrrol-3-yl)methylene]-1-(4-fluorophenyl)-2-thiobarbituric acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and MS analyses. We support development and research needs with custom synthesis and purity grades tailored to specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture and contamination.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (HPLC)	≥ 98.0% / ≥ 99.0% (Higher Grades Available)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.