Description

H-[15N]Val-Oh is a stable isotope-labeled derivative of the amino acid L-Valine, specifically enriched with Nitrogen-15 at the amino position. This compound is a critical reagent for advanced research and analytical applications requiring precise isotopic tracing. It is primarily utilized by scientists and manufacturers in the fields of pharmaceutical development, metabolic research, and analytical chemistry. The product is supplied under stringent quality control to ensure isotopic enrichment and chemical purity for reliable experimental results.

Application

• Metabolic Pathway Tracing: As a 15N-labeled precursor in NMR and mass spectrometry studies to investigate amino acid metabolism and protein turnover.
• Pharmaceutical Research: Synthesis of isotopically labeled drug candidates or internal standards for pharmacokinetic and bioanalytical studies.
• Proteomics & Biomarker Discovery: Used in quantitative proteomics workflows (e.g., SILAC) for accurate protein quantification and identification.
• Nutritional Science: Research into nitrogen balance, amino acid utilization, and protein synthesis in clinical and animal studies.
• Environmental Science: Tracing nitrogen cycling and amino acid assimilation in ecological and microbiological systems.
• Quality Control Standards: Serving as a certified reference material for calibrating analytical instruments in testing laboratories.

Basic Information

Product Name	H-[15N]Val-Oh
CAS No.	59935-29-4
Molecular Formula	C5H1115NO2
Molecular Weight	118.15 g/mol (for 15N isotopologue)
Synonyms	(2S)-2-Amino-3-methylbutanoic-15N acid; L-Valine-15N; L-Valine (amino-15N); Valine-15N; (S)-2-Azanyl-15N-3-methylbutanoic acid; 15N-L-Valine; Stable Isotope Labeled Valine; Amino-15N-L-valine
EINECS	Contact for details

Quality Control

Every batch of H-[15N]Val-Oh is manufactured and tested to meet the exacting standards required for research and analytical use. Our quality assurance includes verification of isotopic enrichment (typically >98 atom % 15N), chemical purity (by HPLC), and chiral purity. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing the results for assay, isotopic purity, specific rotation, and residual solvent analysis. We adhere to cGMP principles for consistent quality and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation and maintain isotopic integrity. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and isotopic label
Assay (HPLC)	≥ 98.0%
Isotopic Purity (15N)	≥ 98 atom %
Specific Rotation	+26° to +30° (c=1 in 5N HCl)
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.