Description

n-α-Carbobenzoxy-L-Serine T-Butyl Ester is a protected amino acid derivative widely used as a key building block in peptide synthesis. This compound is essential for researchers and manufacturers requiring high-purity intermediates to construct complex peptides and active pharmaceutical ingredients (APIs). It is primarily needed by the pharmaceutical, biotechnology, and fine chemical industries for applications in drug discovery, development, and production.

Application

• Solid-Phase Peptide Synthesis (SPPS): A critical protected serine derivative for the sequential assembly of peptides on resin.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for constructing peptide fragments in solution.
• Pharmaceutical Intermediate: Serves as a key raw material in the synthesis of peptide-based drugs and therapeutic agents.
• Bioconjugation and Labeling: The carbobenzoxy (Cbz) protecting group allows for selective deprotection, enabling site-specific modifications.
• Research & Development: Employed in academic and industrial R&D for exploring new peptide structures and biological activities.
• Production of Custom Peptides: A fundamental component for CROs and CDMOs offering bespoke peptide manufacturing services.

Basic Information

Product Name	n-α-Carbobenzoxy-L-Serine T-Butyl Ester
CAS No.	59859-77-7
Molecular Formula	C15H21NO5
Molecular Weight	295.33 g/mol
Synonyms	Nα-Cbz-L-serine tert-butyl ester; Z-Ser-OtBu; CBZ-L-Serine t-Butyl Ester; (S)-2-(((Benzyloxy)carbonyl)amino)-3-hydroxypropanoic acid tert-butyl ester; N-Carbobenzoxy-L-serine tert-butyl ester; L-Serine, N-[(phenylmethoxy)carbonyl]-, 1,1-dimethylethyl ester; Boc-Ser-OBzl (common misnomer, correct is Cbz); Benzyl N-[(2S)-3-hydroxy-1-oxo-1-[(2-methylpropan-2-yl)oxy]propan-2-yl]carbamate
EINECS	Contact for details

Quality Control

Our n-α-Carbobenzoxy-L-Serine T-Butyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical and research applications. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation [α]D20	Specific range available on COA
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.