Description

2,4,6-Trichlorophenyl 5-Oxo-L-Prolinate is a specialized chiral building block and protected amino acid derivative. This compound is significant for its role in the synthesis of complex peptides and peptidomimetics, where it provides a protected proline-like scaffold. It is primarily needed by research institutions and pharmaceutical companies engaged in advanced medicinal chemistry, process development, and the production of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of novel peptide-based drugs and protease inhibitors.
• Peptide Chemistry Research: Used in solid-phase and solution-phase peptide synthesis to introduce modified proline residues.
• Medicinal Chemistry: Serves as a building block for creating compound libraries to screen for new biological activities.
• Process Development: Employed in the scale-up and optimization of synthetic routes for target molecules in API manufacturing.
• Bioconjugation: Potential use in the development of antibody-drug conjugates (ADCs) or other bioconjugates requiring specific linker chemistry.
• Academic Research: Utilized in university and institutional labs for studying peptide structure-activity relationships and developing new synthetic methodologies.

Basic Information

Product Name	2,4,6-Trichlorophenyl 5-Oxo-L-Prolinate
CAS No.	59850-84-9
Molecular Formula	C11H8Cl3NO3
Molecular Weight	300.54 g/mol
Synonyms	L-Pyroglutamic Acid 2,4,6-Trichlorophenyl Ester; 5-Oxo-L-proline 2,4,6-Trichlorophenyl Ester; (S)-5-Oxopyrrolidine-2-carboxylic Acid 2,4,6-Trichlorophenyl Ester; 2,4,6-Trichlorophenyl L-Pyroglutamate; 2,4,6-Trichlorophenyl (S)-5-Oxopyrrolidine-2-carboxylate; L-Pyroglutamic Acid Trichlorophenyl Ester; 5-Oxo-L-proline Trichlorophenol Ester
EINECS	Contact for details

Quality Control

Our 2,4,6-Trichlorophenyl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.