Description

Angiotensin II, Sar(1)- is a potent synthetic peptide analog of the endogenous vasoconstrictor hormone Angiotensin II, specifically modified at the first amino acid position with sarcosine (Sar). This modification enhances its stability and receptor-binding affinity, making it a critical research tool for studying the renin-angiotensin system (RAS). It is essential for pharmaceutical R&D, biochemical research, and as a reference standard in cardiovascular and renal physiology studies. Our supply ensures high purity and batch-to-batch consistency for reliable experimental results.

Application

• Biomedical Research: Fundamental studies on the renin-angiotensin system (RAS), blood pressure regulation, and vascular biology.
• Pharmacological Assays: Used as a reference agonist or antagonist in receptor-binding studies and functional assays for drug discovery targeting hypertension and heart failure.
• Reference Standard: Serves as a high-purity analytical standard for quality control in peptide synthesis and for calibrating bioanalytical methods (HPLC, MS).
• Biochemical Reagent: Employed in enzyme studies, signal transduction pathway analysis, and cell culture experiments to induce specific physiological responses.
• Academic & Institutional Research: A key reagent for universities and research institutes investigating cardiovascular diseases, endocrinology, and peptide hormone action.

Basic Information

Product Name	Angiotensin II, Sar(1)-
CAS No.	59680-38-5
Molecular Formula	C49H70N14O11
Molecular Weight	1031.2 g/mol
Synonyms	Sar1-Angiotensin II; [Sar1]-Angiotensin II; Saralasin Acetate; 1-Sarcosine-8-Isoleucine Angiotensin II; 1-Sar-8-Ile-Angiotensin II; Angiotensin II (1-8) heptapeptide, 1-sarcosine-; Sarcosine1, Isoleucine8 Angiotensin II; (Sar1,Ile8)-Angiotensin II
EINECS	Contact for details

Quality Control

Our Angiotensin II, Sar(1)- is manufactured under strict quality systems to meet the exacting standards of research and development. Each batch undergoes comprehensive analytical testing, including HPLC for purity and mass spectrometry for identity confirmation. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your internal quality protocols. Specifications can be aligned with common pharmacopeial guidelines for peptide reference standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.