Description

Alamethicin is a potent, channel-forming peptide antibiotic isolated from the fungus *Trichoderma viride*. This compound is of significant value in biochemical and biophysical research due to its ability to form voltage-gated ion channels in lipid membranes, making it a critical tool for studying membrane permeability and electrophysiology. It is primarily sought by researchers and manufacturers in the life sciences, pharmaceutical development, and agrochemical sectors for its unique biological activity.

Application

• Membrane Biophysics Research: As a model ion channel-forming agent for studying membrane transport, pore formation, and electrical properties of lipid bilayers.
• Antimicrobial Studies: Investigation of its mechanism of action against gram-positive bacteria and fungi for potential therapeutic applications.
• Drug Delivery Systems: Exploration of its channel-forming properties to enhance the permeability of cell membranes for drug candidates.
• Biochemical Assays: Used as a reagent in assays designed to measure membrane potential, ion flux, and cytotoxicity.
• Agricultural Research: Study of its fungicidal properties for potential use in crop protection formulations.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery of novel antimicrobial peptides.

Basic Information

Product Name	Alamethicin
CAS No.	59588-86-2
Molecular Formula	C92H150N22O25
Molecular Weight	1964.3 g/mol
Synonyms	Alamethicin I; Alamethicin F30; Antibiotic U-22324; Trichotoxin A; L-22324; NSC 326017; Peptaibol Alamethicin; [Ile7]-Alamethicin; [Glu18]-Alamethicin; [Glu18]-Alamethicin I
EINECS	Contact for details

Quality Control

Our Alamethicin is produced and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as purity, identity, and impurity profile. We adhere to relevant industry standards for research-grade biochemicals, ensuring reliable performance for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and easily oxidized; for long-term storage, it is recommended to keep the container under an inert atmosphere such as argon or nitrogen. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Solubility	Soluble in ethanol, DMSO, DMF; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.