Description

α-Endorphin, 10-De-L-Serine-11-De-L-Glutamine-12-De-L-Threonine-13-De-L-Proline-14-De-L-Leucine-15-De-L-Valine-16-De-L-Threonine is a synthetic, truncated analog of the endogenous neuropeptide α-endorphin, designed for enhanced stability and specificity in research applications. This high-purity peptide is critical for advancing neurobiological and pharmacological studies, offering researchers a reliable tool to investigate opioid receptor interactions and pain modulation pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on neuroscience, analgesic development, and peptide-based therapeutics.

Application

• Neuroscience Research: A key tool for studying the endogenous opioid system, receptor binding affinity (mu, delta, kappa), and signal transduction mechanisms.
• Analgesic Drug Discovery: Serves as a reference standard and lead compound in the development of novel, non-addictive pain management therapies.
• Biochemical Assays: Used in competitive binding assays, ELISA development, and functional cellular assays to quantify biological activity.
• Pharmacology Studies: Enables investigation of peptide stability, metabolism, and structure-activity relationships (SAR) in vitro and in vivo.
• Academic & Clinical Research: Supports fundamental research into stress response, mood regulation, and the neurochemical basis of behavior.
• Reference Standard: Provides a high-purity calibrant for analytical methods including HPLC and mass spectrometry in quality control laboratories.

Basic Information

Product Name	α-Endorphin, 10-De-L-Serine-11-De-L-Glutamine-12-De-L-Threonine-13-De-L-Proline-14-De-L-Leucine-15-De-L-Valine-16-De-L-Threonine
CAS No.	59481-79-7
Molecular Formula	C73H113N19O22
Molecular Weight	1560.8 g/mol
Synonyms	α-Endorphin (des-Ser1-Gln2-Thr3-Pro4-Leu5-Val6-Thr7); Des-Ser1-Des-Gln2-Des-Thr3-Des-Pro4-Des-Leu5-Des-Val6-Des-Thr7-α-Endorphin; α-Endorphin (1-9); α-Endorphin fragment 1-9; LPH-(61-69); Lipotropin-(61-69); β-Lipotropin-(61-69); Synthetic α-endorphin analog
EINECS	Contact for details

Quality Control

Our α-Endorphin analog is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. For custom synthesis or GMP-grade material, please contact our technical sales team.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep the primary container in a desiccated environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by AAA)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.