Description

8-Chloro-6-(o-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate belonging to the imidazobenzodiazepine class. This compound is critical for the research and development of novel therapeutic agents, particularly in the central nervous system (CNS) sector. It is primarily sought by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in synthesizing new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel benzodiazepine-derived active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new compounds targeting GABAA receptors.
• Preclinical Drug Development: Serves as a critical precursor for candidate drugs in neurological and psychiatric disorder research.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in analytical laboratories.
• Process Chemistry: Employed in route scouting and optimization for scalable API manufacturing processes.
• Academic Research: Used in university and institutional labs for pharmacological studies and heterocyclic chemistry exploration.

Basic Information

Product Name	8-Chloro-6-(o-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid
CAS No.	59468-44-9
Molecular Formula	C19H13ClFN3O2
Molecular Weight	369.78 g/mol
Synonyms	8-Chloro-6-(2-fluorophenyl)-1-methyl-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid; Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-chloro-6-(2-fluorophenyl)-1-methyl-4H-; Ro 48-6791 carboxylic acid; Midazolam related compound; Zolpidem intermediate; GABA receptor ligand intermediate; 59468-44-9
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-(o-Fluorophenyl)-1-Methyl-4H-Imidazo[1,5-A][1,4]Benzodiazepine-3-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements. Specifications are designed to meet the stringent needs of pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.