Description

1-Chloro-5-Oxo-L-Proline is a high-purity chiral building block and synthetic intermediate of significant interest in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in the development of novel pharmaceuticals and bioactive compounds. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for peptide modification and the synthesis of specialized active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for protease inhibitors and other targeted therapies.
• Peptide Chemistry: Used for the selective modification and derivatization of peptides, enabling the study of structure-activity relationships.
• Bioconjugation: Serves as a reactive handle for linking biomolecules in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Organic Synthesis: Employed as a versatile building block in asymmetric synthesis and for introducing the proline scaffold into complex organic molecules.
• Biochemical Research: Utilized in academic and industrial R&D for studying enzyme mechanisms and as a precursor for labeled compounds.

Basic Information

Product Name	1-Chloro-5-Oxo-L-Proline
CAS No.	59384-02-0
Molecular Formula	C5H6ClNO3
Molecular Weight	163.56 g/mol
Synonyms	(S)-1-Chloropyrrolidine-2,5-dione; L-1-Chloro-5-oxopyrrolidine-2-carboxylic Acid; 1-Chloro-L-proline-5-lactone; 1-Chloro-5-oxo-L-proline lactone; 1-Chloro-5-oxo-L-proline; 1-Chloro-5-oxoproline; 1-Chloropyroglutamic Acid; 1-Chloro-5-oxo-L-2-pyrrolidinecarboxylic Acid
EINECS	Contact for details

Quality Control

Our 1-Chloro-5-Oxo-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for research and synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.