Description

Acth Nonadecapeptide (1-19), Aib(1)-Lys(17,18,19)- is a synthetic peptide analog of the N-terminal fragment of adrenocorticotropic hormone (ACTH). This compound is of significant interest for its enhanced stability and biological activity profile compared to the native sequence. It serves as a critical research tool and intermediate for pharmaceutical development, particularly in endocrinology and metabolic disorder research. Key industries requiring this high-purity peptide include pharmaceutical R&D, biotechnology, and advanced chemical synthesis.

Application

• Pharmaceutical Research & Development: As a stable ACTH analog for studying adrenal cortex function, steroidogenesis, and related metabolic pathways.
• Reference Standard: Used as a high-purity calibrant or control material in analytical methods (HPLC, MS) for quality control of peptide-based pharmaceuticals.
• Biochemical Studies: Investigation of peptide-receptor interactions, structure-activity relationships (SAR), and signal transduction mechanisms.
• Intermediate for Conjugation: Serves as a building block for the synthesis of more complex peptide-drug conjugates or labeled probes (e.g., fluorescent, radioactive).
• Academic Research: Fundamental studies in endocrinology, neurobiology, and peptide chemistry within university and institutional laboratories.

Basic Information

Product Name	Acth Nonadecapeptide (1-19), Aib(1)-Lys(17,18,19)-
CAS No.	59189-13-8
Molecular Formula	C₁₀₈H₁₆₅N₃₁O₃₁
Molecular Weight	2463.7 g/mol (approx.)
Synonyms	ACTH (1-19), Aib(1),Lys(17),Lys(18),Lys(19)-; Adrenocorticotropic Hormone (1-19) fragment, Aib-1, Lys-17,18,19 substituted; H-Aib-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Lys-OH; Norleusactide; [Aib1, Lys17, Lys18, Lys19]-ACTH (1-19); ACTH (1-19) analog; Synthetic ACTH fragment.
EINECS	Contact for details

Quality Control

Our Acth Nonadecapeptide (1-19), Aib(1)-Lys(17,18,19)- is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for related substances and residual solvents. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Single Impurity (HPLC)	≤ 1.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.