Description

α-Endorphin CAS NO 59004-96-5 is a bioactive endogenous opioid peptide, a fragment of the proopiomelanocortin (POMC) precursor protein. This compound is of significant interest for its role in modulating pain perception, stress response, and immune function within the central nervous system. It is primarily utilized by research institutions, pharmaceutical developers, and diagnostic manufacturers focused on neurobiology, analgesia, and peptide-based therapeutic discovery.

Application

• Neuroscientific Research: Used as a reference standard and experimental tool to study opioid receptor interactions, signal transduction pathways, and the neurobiology of pain and reward.
• Pharmaceutical R&D: Serves as a key starting material or biological target in the development of novel analgesic drugs and central nervous system (CNS) therapeutics.
• Biochemical Assays: Employed in competitive binding assays (e.g., ELISA, RIA) and receptor characterization studies to quantify biological activity and potency.
• Diagnostic Development: Acts as a critical antigen or calibrator in the production of immunoassays and test kits designed to detect endorphin levels or related biomarkers.
• Cell Culture & Physiology Studies: Applied in vitro to investigate the effects of opioid peptides on cell proliferation, cytokine release, and neuroendocrine functions.

Basic Information

Product Name	α-Endorphin
CAS No.	59004-96-5
Molecular Formula	C77H120N18O26S
Molecular Weight	1746.0 g/mol
Synonyms	α-Endorphin; Endorphin, α-; LPH-(61-76); β-Lipotropin (61-76); Met-enkephalin-Arg6-Phe7; Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-Val-Thr; [Met5]-Enkephalin-Arg6-Phe7
EINECS	Contact for details

Quality Control

Our α-Endorphin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC, identity confirmation by mass spectrometry, and verification of biological activity. Certificates of Analysis (COA) detailing batch-specific results are provided to ensure full traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Biological Activity	Assessed by receptor binding assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.