Description

2-Formyl-3-(Trifluoromethyl)Phenol, 2-Formyl-3-Hydroxybenzotrifluoride, 6-(Trifluoromethyl)Salicylaldehyde CAS NO 58914-35-5 is a versatile trifluoromethylated aromatic aldehyde, a key building block prized for its unique combination of a reactive formyl group, a phenolic hydroxyl, and a stable trifluoromethyl substituent. This trifluoromethyl group is a critical structural motif that enhances the lipophilicity, metabolic stability, and binding affinity of target molecules, making it invaluable in advanced synthesis. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial precursor in synthesizing drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anti-infectives, where the CF3 group improves pharmacokinetic properties.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group contributes to enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating sophisticated chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Precursor: Employed in the synthesis of advanced polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic units for specific optical or electronic properties.
• Chemical Research & Development: A fundamental reagent for exploring novel organic reactions, heterocyclic chemistry (e.g., benzoxazoles, chromones), and the synthesis of complex natural product analogs.

Basic Information

Product Name	2-Formyl-3-(Trifluoromethyl)Phenol / 6-(Trifluoromethyl)Salicylaldehyde
CAS No.	58914-35-5
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	2-Formyl-3-hydroxybenzotrifluoride; 6-(Trifluoromethyl)salicylaldehyde; 2-Hydroxy-3-(trifluoromethyl)benzaldehyde; 3-(Trifluoromethyl)salicylaldehyde; 2-Hydroxy-α,α,α-trifluoro-m-tolualdehyde; 3-Trifluoromethyl-2-hydroxybenzaldehyde; Salicylaldehyde, 6-(trifluoromethyl)-; m-Trifluoromethylsalicylaldehyde
EINECS	Contact for details

Quality Control

Our 2-Formyl-3-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent composition suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere for long-term storage). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.