Description

Secretin (5-27), Gln(9) is a synthetic peptide fragment of the gastrointestinal hormone secretin, specifically the sequence from amino acids 5 to 27 with a glutamine substitution at position 9. This compound is a crucial research-grade biochemical tool for studying pancreatic secretion, bicarbonate regulation, and receptor-ligand interactions in digestive physiology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic and gastrointestinal disorders.

Application

• Biomedical Research: Used as a reference standard and active agent in studies of secretin receptor (SCTR) signaling pathways and pancreatic function.
• Drug Discovery & Development: Serves as a key pharmacological tool for screening and validating potential therapeutics targeting secretin-related pathways.
• In Vitro Diagnostics (IVD): Employed in the development and calibration of immunoassays and diagnostic kits for measuring secretin or related biomarkers.
• Academic & Clinical Studies: Facilitates fundamental research into gastrointestinal physiology, hormone action, and fluid/electrolyte balance.
• Peptide Chemistry & Synthesis: Acts as a model compound for developing and optimizing peptide synthesis, purification, and analytical methodologies.

Basic Information

Product Name	Secretin (5-27), Gln(9)
CAS No.	58886-96-7
Molecular Formula	C115H179N35O49S2
Molecular Weight	2695.0 g/mol (approx.)
Synonyms	Secretin (5-27) amide, Gln9-Secretin(5-27); [Gln9]-Secretin (5-27); Secretin fragment 5-27 (Gln9); H-His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Asp-Ser-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2; SCT (5-27), Gln9; Gastrointestinal peptide fragment
EINECS	Contact for details

Quality Control

Our Secretin (5-27), Gln(9) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and amino acid analysis (AAA). Certificates of Analysis (COA) detailing purity, peptide content, and impurity profiles are available upon request to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Composition	Within ±10% of theoretical
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.