Description

[Leu5]-Enkephalin CAS NO 58822-25-6 is a synthetic pentapeptide and a potent opioid receptor agonist, structurally analogous to endogenous enkephalins. This compound is a critical research tool for neurobiological studies, enabling the investigation of pain pathways, opioid receptor function, and neurotransmitter signaling. It is essential for pharmaceutical R&D, academic research, and biochemical applications focused on neuroscience and analgesic drug discovery.

Application

• Neuroscience Research: A standard ligand for studying opioid receptor (delta and mu) binding, activation, and downstream signaling pathways in vitro and in vivo.
• Pharmacological Studies: Used to investigate the mechanisms of analgesia, tolerance, and dependence in preclinical models of pain management.
• Biochemical Assay Standard: Serves as a reference standard in HPLC, LC-MS, and immunoassays for the quantification of enkephalins and related peptides.
• Cell Signaling Research: Applied in studies examining the role of endogenous opioids in neuroprotection, mood regulation, and immune modulation.
• Drug Discovery & Development: A key compound for screening and developing novel analgesic agents with improved efficacy and reduced side-effect profiles.
• Academic & Educational Use: Utilized in university laboratories for teaching advanced concepts in neuropharmacology and peptide chemistry.

Basic Information

Product Name	[Leu5]-Enkephalin
CAS No.	58822-25-6
Molecular Formula	C28H37N5O7
Molecular Weight	555.63 g/mol
Synonyms	Leucine Enkephalin; Leu-Enkephalin; YGGFL; H-Tyr-Gly-Gly-Phe-Leu-OH; (5-L-Leucine)enkephalin; Opioid Growth Factor (OGF) [Leu5]; L-Enkephalin
EINECS	Contact for details

Quality Control

Our [Leu5]-Enkephalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS for identity confirmation, and tests for residual solvents and moisture content. Certificates of Analysis (COA) are provided, detailing all specifications and results. We support research and development with materials suitable for advanced applications, ensuring reliable performance and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.